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- Talk to your care team right away if you have changes in mood or behavior or thoughts of self-harm or suicide.
- There are no adequate and well-controlled studies with LYRICA in pregnant women.
- Clinical evidence examining treatment sequences and long-term outcomes could inform more realistic model structures that better reflect clinical practice patterns.
- The mean duration of epilepsy was 6 years and the mean and median baseline seizure frequencies were 57 and 18 seizures per month, respectively.
- This website is for informational purposes only and should not be considered as medical advice, diagnosis or treatment.
What side effects may I notice from receiving this medication?
The effect on offspring survival was pronounced at doses greater than or equal to 1250 mg/kg, with 100% mortality in high-dose litters. When offspring were tested as adults, neurobehavioral abnormalities (decreased auditory startle responding) were observed at greater than or equal to 250 mg/kg and reproductive impairment (decreased fertility and litter size) was seen at 1250 mg/kg. The no-effect dose for pre- and postnatal developmental toxicity in rats (50 mg/kg) produced a plasma exposure approximately 2 times human exposure at the MRD. In all controlled and uncontrolled trials across various patient populations during the premarketing development of LYRICA, more than 10,000 patients have received LYRICA.